How Psychedelics Work: Fire the Conductor, Let the Orchestra Play | Michael Pollan | Big Think

If your ego had a "location" in the brain, it would be the default mode network, where much of your self-critical mind chatter happens. Taking psychedelics down-regulates this brain network. Researchers describe the effect of psychedelics as "letting the brain off its leash", or firing the conductor to let the orchestra play. Without the default mode network acting as a dictator, areas of the brain that don't normally interact meet, producing phenomena like hallucinations and synesthesia.