While the use of psychedelic substances dates back to ancient times, research into their effects and uses was effectively shut down until recently. LSD was first discovered in 1943, and a significant interest developed in the potential psychotherapeutic uses of it and other psychedelic drugs; however, with the rise of the 1960s counterculture movement and its adaptation of psychedelics as an act of rebellion against society, the drugs were deemed dangerous, made illegal, and effectively banned from research. Modern researchers are once again delving into their potential benefits in treating a multitude of issues—from anxiety, depression, and PTSD, to brain injury and even the fear of death associated with terminal cancer.