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As Psychedelics Revival Rolls On, Don't Downplay Bad Trips

By John Horgan — 2015

I'm no psychedelic prude. I reported on, and applauded, the resurgence of research into psychedelics in my 2003 book Rational Mysticism. I participated in a peyote ceremony of the Native American Church, and I advocated legalization of psychedelics for therapeutic purposes. But the enthusiasm with which some journalists are now touting psychedelics makes me a bit uneasy.

Read on blogs.scientificamerican.com

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A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience

Using pharmacokinetic modeling and DMT blood sampling data, we demonstrate that the unique pharmacological characteristics of DMT, which also include a rapid onset and lack of acute tolerance to its subjective effects, make it amenable to administration by target-controlled intravenous infusion.

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Andrew R. Gallimore and Rick J. Strassman
2016
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Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

Taken together, our results suggest that psychedelic microdosing may alleviate symptoms of mood and anxiety disorders, though the potential hazards of this practice warrant further investigation.

Article
Lindsay P. Cameron, Charlie J. Benson, Brian C. DeFelice, Oliver Fiehn, and David E. Olson
2019
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DMT Alters Cortical Travelling Waves

These results support a recent model proposing that psychedelics reduce the ‘precision-weighting of priors’, thus altering the balance of top-down versus bottom-up information passing.

Article
Andrea Alamia, Christopher Timmermann, David J Nutt, Rufin VanRullen, Robin L Carhart-Harris
2020
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Would You Consider Trying Psychedelics to Take Your Practice to Another Level?

Here, we explore the potential role of psychedelics within a yoga practice or as therapeutic treatment.

Article
Amanda Tust
2019
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The Trip Treatment

Research into psychedelics, shut down for decades, is now yielding exciting results.

Article
Michael Pollan
2015
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How Ecstasy and Psilocybin Are Shaking Up Psychiatry

Regulators will soon grapple with how to safely administer powerful psychedelics for treating depression and post-traumatic stress disorder.

Article
Paul Tullis
2021
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The Return of Psychedelics to Counseling: Are We Ready?

Those of us who are professional counselors are perhaps most likely to recognize psychedelic drugs by their recreational or street names — acid, magic mushrooms, ecstasy — and to consider them to be drugs of abuse that may be dangerous to our clients.

Article
Benjamin Hearn
2020
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MDMA Lauded as ‘Breakthrough’ Therapy for PTSD Patients

The Food and Drug Administration (FDA) has approved the design of two Phase 3 clinical trials of MDMA for treating PTSD, according to the Multidisciplinary Association for Psychedelic Studies (MAPS), which is funding and leading the clinical trials.

Article
Maureen Meehan
2017
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Johns Hopkins Scientists Give Psychedelics the Serious Treatment

Psychedelic drugs—once promising research subjects that were decades ago relegated to illicit experimentation in dorm rooms—have been steadily making their way back into the lab for a revamped 21st-century-style look.

Article
Tanya Lewis
2020
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Can Psychedelic Experiences Cure Alcohol Addiction?

A new study hints at a novel and promising treatment for alcohol use disorder.

Article
Mark Travers
2019
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Altered States of Consciousness